Giant omphaloceles are associated with a considerable loss of abdominal domain. Early
primary repair of the fascia is either not possible or poorly tolerated by the infant. Current
surgical options result in a ventral hernia requiring future surgery or involve the chronic use
of prosthetic patches with or without tissue expanders. This case presentation describes an
alternative surgical approach that results in early fascial closure using an interposition graft
of Alloderm.